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By Paul Peter Rosen and Harold A. Oberman
The expanded size and scope of this third edition of Tumors of the Mammary Gland reflect the explosive growth of information relating to breast disease that has occurred in the last 25 years. The comprehensive text begins with an introduction that traces the controversial issue of precancerous or proliferative breast lesions from the first fascicle (authored in 1950 by Stewart) to the present. Nearly 25% of the 382 pages of text and 593 illustrations are devoted to the pathology of benign proliferative lesions, atypical hyperplasia, and in-situ carcinoma. The classification of mammary tumors employed in this volume is based on one adopted by the World Health Organization in 1981. However, the listing has been substantially expanded to include more than 20 specific entities described in succeeding years. Subheadings have also been added for a number of clinicopathologic conditions with distinctive pathologic characteristics such as occult carcinoma presenting with axillary lymph node metastases. The text includes sections on mammary gland anatomy, developmental and physiological abnormalities, and inflammatory conditions. Extensively illustrated sections describe benign proliferative lesions, benign epithelial tumors, fibroepithelial neoplasms (fibroadenoma and cystosarcoma), atypical hyperplasia and in-situ carcinoma of lobules and ducts, 17 subtypes of invasive carcinoma, breast tumors in children, tumors of the male breast, mesenchymal tumors, and Iymphoid neoplasms. Separate sections are devoted to the TNM staging of carcinoma, unusual clinical manifestations of breast carcinoma, the pathology of axillary lymph nodes, cytologic diagnosis of breast lesions, and the pathologic examination of breast specimens. Of particular note are discussions of papillary neoplasms, atypical hyperplasia and in-situ carcinoma, prognostic markers in carcinoma, and vascular neoplasms. The detailed histopathological descriptions consider differential diagnosis and discuss the role of immunohistochemistry, electron microscopy, and other procedures for establishing the pathologic diagnosis. The clinical characteristics of the lesions are described, and the current treatment options reported in the literature are summarized.